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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EGFR
All Species:
23.64
Human Site:
Y944
Identified Species:
47.27
UniProt:
P00533
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P00533
NP_005219.2
1210
134277
Y944
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
Chimpanzee
Pan troglodytes
XP_519102
1210
134401
Y944
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
Rhesus Macaque
Macaca mulatta
XP_001107305
1120
124266
L861
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Dog
Lupus familis
XP_533073
1595
175523
Y1332
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
Cat
Felis silvestris
Mouse
Mus musculus
Q01279
1210
134835
Y946
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
Rat
Rattus norvegicus
Q62956
1308
146940
Y950
P
I
C
T
I
D
V
Y
I
V
M
V
K
C
W
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507339
1187
132966
Y919
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
Chicken
Gallus gallus
P13387
703
77409
S444
T
K
Q
H
G
Q
Y
S
L
A
V
V
N
L
K
Frog
Xenopus laevis
Q91694
985
109711
M725
T
V
I
Q
L
V
G
M
L
R
G
I
G
S
G
Zebra Danio
Brachydanio rerio
NP_919405
1191
132465
K928
E
I
A
G
V
L
E
K
G
E
R
L
P
Q
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P04412
1426
159700
C1165
K
L
E
Q
P
E
I
C
S
L
D
I
Y
C
T
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P24348
1323
150493
Q1004
G
M
Q
Y
L
E
K
Q
R
V
V
H
R
D
L
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
90.3
69.5
N.A.
90.5
49.4
N.A.
82.1
42.4
21.8
62.4
N.A.
35.2
N.A.
27.7
N.A.
Protein Similarity:
100
99.6
91.4
72.6
N.A.
95
64.6
N.A.
88.4
48.2
37.4
74
N.A.
51.1
N.A.
46.7
N.A.
P-Site Identity:
100
100
0
100
N.A.
100
86.6
N.A.
100
6.6
0
6.6
N.A.
6.6
N.A.
0
N.A.
P-Site Similarity:
100
100
20
100
N.A.
100
100
N.A.
100
20
26.6
20
N.A.
40
N.A.
40
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
9
0
0
9
0
0
0
9
9
0
0
0
0
% A
% Cys:
0
0
50
0
0
0
0
9
0
0
0
0
0
59
0
% C
% Asp:
0
9
0
0
0
50
0
0
0
0
9
0
0
9
0
% D
% Glu:
9
0
9
0
0
17
9
0
0
9
0
9
9
0
9
% E
% Phe:
0
0
9
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
9
0
0
17
9
0
9
0
9
9
9
0
9
0
9
% G
% His:
0
0
0
9
0
0
0
0
0
0
0
9
0
0
0
% H
% Ile:
0
59
9
0
50
0
9
0
9
42
0
17
0
0
0
% I
% Lys:
9
9
0
0
0
0
17
9
0
0
0
0
50
9
9
% K
% Leu:
0
9
0
0
25
9
0
9
25
9
0
9
0
9
9
% L
% Met:
0
9
0
0
0
0
0
9
42
0
50
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% N
% Pro:
50
0
0
0
9
0
0
0
0
0
0
0
9
0
9
% P
% Gln:
0
0
17
17
0
9
0
9
0
0
0
0
0
9
0
% Q
% Arg:
0
0
0
0
0
0
0
0
9
9
9
0
9
0
0
% R
% Ser:
0
0
0
0
0
0
0
9
9
0
0
0
0
9
0
% S
% Thr:
25
0
0
50
0
0
0
0
0
0
0
0
0
0
9
% T
% Val:
0
9
0
0
9
9
50
0
0
17
17
59
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
50
% W
% Tyr:
0
0
0
9
0
0
9
50
0
0
0
0
9
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _